p-Toluenesulfonic acid → HCID 54464049, compound

Participants

Reaction Steps

In 5 ml of absolute methanol was dissolved 100 mg of 1-(3,4-bistetrahydropyranyloxyphenyl)-6-(3,4-dimethoxyphenyl)-3-oxo-1-hexene obtained in Example 15-(1). A catalytic amount of p-toluenesulfonic acid was added to the solution at 0° C. and a stirring was effected at the same temperature for 1 hour. After the reaction, 1 drop of triethylamine was added to the reaction mixture and then the mixture was concentrated to give crude product. By purification of the crude product by means of column chromatography (silica gel/hexane:ethyl acetate=1:1), 55 mg of the above caption compound was obtained.

Provenance & Evidence