HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Pyrrolidino-5-chloro-1,2-dihydronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 8-Chloro-1,2,3,4-tetrahydronaphthalen-2-one | HCID 4623269 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-Pyrrolidino-5-chloro-1,2-dihydronaphthalene | HCID 15137221 | — |
Reaction Steps
70.0 g of 8-chloro-3,4-dihydro-2(1H)-naphthalenone were boiled at reflux for 2.5 hours in 550 ml of benzene and 33 ml of pyrrolidine in the presence of 1.4 g of p-toluenesulphonic acid. The crude 1-(8-chloro-3,4-dihydro-2-naphthyl)-pyrrolidine obtained was processed without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04732979 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-2e532bae59fb445ea10542b5a44aa5ef |
| Source note | uspto-grants-1988_03 |