5-Aminobenzimidazole → HCID 86297342, compound

HRID 56965Notes

Reaction equation

HRID 56965 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:20]#[N:21])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH3:18])[C:15]([OH:17])=O)[C:10](=[O:19])[CH:9]=2)[CH:7]=1.[NH:22]1[C:26]2[CH:27]=[C:28]([NH2:31])[CH:29]=[CH:30][C:25]=2[N:24]=[CH:23]1>>[NH:22]1[C:26]2[CH:27]=[C:28]([NH:31][C:15](=[O:17])[CH:14]([N:11]3[CH:12]=[CH:13][C:8]([C:6]4[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=4[C:20]#[N:21])=[CH:9][C:10]3=[O:19])[CH3:18])[CH:29]=[CH:30][C:25]=2[N:24]=[CH:23]1

Participants

3

Reactant 2

HCID 136235-AminobenzimidazoleHCID 1176228502-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

Product 1

HCID 86297342HCID 86297342, compound

Procedure

65 mg (purity 83%, 0.18 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) (Example 2.2B) and 26 mg (0.20 mmol) of 1H-benzimidazole-6-amine were reacted according to General Method 1. Yield: 11 mg (15% of theory)

Sources & evidence

ORD record
ord-473afc31248d4826bc397e74117ee64c
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

Loading…