反应详情

7.00 g (0.032 mol) of 8-chloro-1,2,3,4,5,6-hexahydrobenzo[f]quinoline were dissolved in 50 ml of pyridine and 6.75 g (0.048 mol) of benzoyl chloride were added dropwise thereto at 0°. After stirring at room temperature overnight the mixture was extracted with water and chloroform, dried with magnesium sulphate and the solvent was distilled off in vacuo. Chromatography (silica gel, chloroform-hexane, 1:1) and crystallization chloroform-hexane) gave 4-benzoyl-8-chloro-1,2,3,4,5,6-hexahydrobenzo[f]-quinoline as white crystals of melting point 194°-196°.

1. customat 0°
2. extractionwas extracted with water and chloroform
3. dry with materialdried with magnesium sulphate
4. distillationthe solvent was distilled off in vacuo
5. customChromatography (silica gel, chloroform-hexane, 1:1) and crystallization chloroform-hexane)