2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]butanoic acid → HCID 178454444, compound

HRID 56966Notes

Reaction equation

HRID 56966 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:21]#[N:22])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:18][CH3:19])[C:15]([OH:17])=O)[C:10](=[O:20])[CH:9]=2)[CH:7]=1.[NH:23]1[C:27]([C:28]2[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=2)=[N:26][N:25]=[N:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:21]#[N:22])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:18][CH3:19])[C:15]([NH:32][C:31]3[CH:33]=[CH:34][C:28]([C:27]4[NH:26][N:25]=[N:24][N:23]=4)=[CH:29][CH:30]=3)=[O:17])[C:10](=[O:20])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 1176227462-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]butanoic acidHCID 178507471HCID 178507471, compound

Product 1

HCID 178454444HCID 178454444, compound

Procedure

212 mg (purity 60%, 0.4 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]butanoic acid (racemate) (Example 3.1C) and 31 mg (0.19 mmol) of 4-(1H-tetrazol-5-yl)aniline were reacted according to General Method 1. Yield: 143 mg (77% of theory)

Sources & evidence

ORD record
ord-53e1b91e63e44a0e9cc8aece88f21324
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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