2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-methylbutanoic acid → HCID 178447220, compound

HRID 56967Notes

Reaction equation

HRID 56967 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:22]#[N:23])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH:18]([CH3:20])[CH3:19])[C:15]([OH:17])=O)[C:10](=[O:21])[CH:9]=2)[CH:7]=1.[NH:24]1[C:28]([C:29]2[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][CH:30]=2)=[N:27][N:26]=[N:25]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:22]#[N:23])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH:18]([CH3:19])[CH3:20])[C:15]([NH:33][C:32]3[CH:34]=[CH:35][C:29]([C:28]4[NH:27][N:26]=[N:25][N:24]=4)=[CH:30][CH:31]=3)=[O:17])[C:10](=[O:21])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 1176226852-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-methylbutanoic acidHCID 178507471HCID 178507471, compound

Product 1

HCID 178447220HCID 178447220, compound

Procedure

79 mg (purity 86%, 0.21 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-methylbutanoic acid (racemate) (Example 4.1C) and 40 mg (0.25 mmol) of 4-(1H-tetrazol-5-yl)aniline were reacted according to General Method 1. Yield: 45 mg (46% of theory)

Sources & evidence

ORD record
ord-6b57cfcea94a41e7a127f7cb21554e57
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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