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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 569679Generated: October 26, 2026

Piperonal → 3-(3,4-Methylenedioxyphenyl)-6-dimethylaminophthalide

https://huagongshe.com/reaction/569679

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperonalHCID 8438—
Reactant3-(Dimethylamino)benzoic acidHCID 66837—
Reactant3-[4-(N-ethylbenzylamino)phenyl]-6-dimethylaminophthalideHCID 54043443—
SolventAcetic AnhydrideHCID 7918—
Product3-(3,4-Methylenedioxyphenyl)-6-dimethylaminophthalideHCID 136517336.1%

Reaction Steps

Following a procedure similar to that described in Example 1, part A above, 7.5 g of 3,4-(methylenedioxy)benzaldehyde and 9.1 g of 3-dimethylaminobenzoic acid were interacted in acetic anhydride to obtain 0.9 g of 3-(3,4-methylenedioxyphenyl)-6-dimethylaminophthalide (Formula II: R=CH3 ; X=H; Y=1-[3,4-(OCH2O)C6H3 ]) a light yellow solid melting over the range 134°-143° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04732991
Source datasetuspto-grants-1988_03
ORD IDord-04041833d8d743f3a10e64c0be38e71d
Source noteuspto-grants-1988_03