2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoic acid → HCID 178445136, compound

HRID 56968Notes

Reaction equation

HRID 56968 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:23]#[N:24])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:18][CH2:19][CH2:20][CH3:21])[C:15](O)=[O:16])[C:10](=[O:22])[CH:9]=2)[CH:7]=1.[NH:25]1[C:29]([C:30]2[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=2)=[N:28][N:27]=[N:26]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:23]#[N:24])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:18][CH2:19][CH2:20][CH3:21])[C:15]([NH:34][C:33]3[CH:35]=[CH:36][C:30]([C:29]4[NH:28][N:27]=[N:26][N:25]=4)=[CH:31][CH:32]=3)=[O:16])[C:10](=[O:22])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 1176228212-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoic acidHCID 178507471HCID 178507471, compound

Product 1

HCID 178445136HCID 178445136, compound

Procedure

95 mg (purity 78%, 0.22 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoic acid (racemate) (Example 5.1C) and 42 mg (0.26 mmol) of 4-(1H-tetrazol-5-yl)aniline were reacted according to General Method 1. Yield: 32 mg (30% of theory)

Sources & evidence

ORD record
ord-b7bf00d2a0604050af99c0cb2f3b8241
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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