Diphosgene → HCID 14099380, compound

Participants

Reaction Steps

To a stirred solution of 3.9 grams (0.017 mole) of 6-amino-7-fluoro-4-propyl-2H-1,4-benzoxazin-3(4H)-one in 240 ml of toluene was added a solution of 2.06 grams (0.0104 mole) of trichloromethylchloroformate in 10 ml of toluene. This mixture was stirred at room temperature for 1.5 hours and then was heated at reflux for approximately 18 hours. The mixture was cooled, and the solvent was removed by distillation at atmospheric pressure leaving a residue. This residue was subjected to reduced pressure for two hours to yield 4.36 grams of 7-fluoro-4-propyl-2H-1,4-benzoxazin-3(4H)-one-6 yl is isocyanate as a brown solid.

Provenance & Evidence