HRID56971

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N#Cc1ccc(Cl)cc1-c1ccn(C(Cc2ccccc2)C(=O)O)c(=O)c1

HCID117622560

未命名化合物

HCID178507471

未命名化合物

PRODUCTS

生成物

结构：CCNCC.N#Cc1ccc(Cl)cc1-c1ccn(C(Cc2ccccc2)C(=O)Nc2ccc(-c3nnn[nH]3)cc2)c(=O)c1

HCID178464401

未命名化合物

PROCEDURE

实验过程

77 mg (purity 85%, 0.17 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-phenylpropanoic acid (racemate) (Example 7.1C) and 31 mg (0.19 mmol) of 4-(1H-tetrazol-5-yl)aniline were reacted according to General Method 1. Yield: 17 mg (purity 94%, 16% of theory)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d01b05569c9341ef977274e7516dae1f
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434690B2
来源说明: uspto-grants-2016_09

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:26]#[N:27])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:15](O)=[O:16])[C:10](=[O:25])[CH:9]=2)[CH:7]=1.[NH:28]1[C:32]([C:33]2[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=2)=[N:31][N:30]=[N:29]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:26]#[N:27])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH2:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:15]([NH:37][C:36]3[CH:38]=[CH:39][C:33]([C:32]4[NH:31][N:30]=[N:29][N:28]=4)=[CH:34][CH:35]=3)=[O:16])[C:10](=[O:25])[CH:9]=2)[CH:7]=1.[CH2:10]([NH:11][CH2:12][CH3:13])[CH3:9]