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0 °C

51.6 g (0.365 mole) of N-sulphinylmethanesulphonamide in 50 ml of benzene are added to a solution of 60 g (0.298 mole) of methyl 3-sulphinylamino-4-methylbenzoate in 200 ml of benzene at room temperature under argon. Thereafter, 24.9 g (0.315 mole) of pyridine, dissolved in 75 ml of benzene, are added in portions to the reaction mixture, while cooling with ice. The mixture is subsequently stirred at 0° C. for 10 minutes and then heated under reflux for 45 hours. After cooling, the benzene and pyridine are distilled off in vacuo, the oil which remains is poured into 150 ml of water and the mixture is acidified to pH 4 with 2N HCl. A brown solid thereby forms from the oil, and is extracted with chloroform. The chloroform extracts are washed with water, dried over MgSO4 and concentrated to dryness. The oil which remains crystallizes to a brown-yellow material by adding n-hexane, and the material is filtered off with suction and washed with n-hexane.

1. additionare added in portions to the reaction mixture
2. temperaturewhile cooling with ice
3. temperatureheated
4. temperatureunder reflux for 45 hours
5. temperatureAfter cooling
6. distillationthe benzene and pyridine are distilled off in vacuo
7. additionthe oil which remains is poured into 150 ml of water
8. extractionA brown solid thereby forms from the oil, and is extracted with chloroform
9. washThe chloroform extracts are washed with water
10. dry with materialdried over MgSO4
11. concentrationconcentrated to dryness
12. customThe oil which remains crystallizes to a brown-yellow material
13. additionby adding n-hexane
14. filtrationthe material is filtered off with suction
15. washwashed with n-hexane