Sodium Hydroxide → HCID 14003420, compound

Participants

Reaction Steps

To 370 ml of an ethanolic suspension containing 37.0 g of ethyl 6-(t-butoxycarbonylamino)-5-phenylhexanoate [prepared as described in step (b) above] were added 79 ml of water containing 8.8 g of sodium hydroxide. The reaction mixture was stirred for 1 hour at room temperature and then the solvent was distilled off under reduced pressure. The residue was mixed with ethyl acetate and water, and the aqueous layer was adjusted to a pH value of 3 by the addition of concentrated hydrochloric acid. The ethyl acetate layer was separated, washed with water and dried over anhydrous magnesium sulfate. Evaporation of the solvent gave quantitatively 6-(t-butoxycarbonylamino)-5-phenylhexanoic acid as a syrupy substance.

Provenance & Evidence