t-Butyl alpha-[3(S*)-azido-2-oxo-6(R*)-phenylperhydroazepin-1-yl]acetate → t-Butyl alpha-[3(S*)-amino-2-oxo-6(R*)-phenylperhydroazepin-1-yl]acetate

Participants

Reaction Steps

0.3 g of 5% w/w palladium-on-carbon was added to 30 ml of ethanol containing 1.4 g of t-butyl α-[3(S*)-azido-2-oxo-6(R*)-phenylperhydroazepin-1-yl]acetate (Isomer A) [prepared as described in Example 1(h)], and under one atmosphere pressure of hydrogen the reaction mixture was shaken for 4 hours at 40° C. The catalyst was filtered off and the solvent was evaporated under reduced pressure, to give 1.56 g of the title compound as a gummy substance.

Provenance & Evidence