HCID 14003457, compound → HCID 14003467, compound

Participants

Reaction Steps

4 ml of a 4N hydrogen chloride/dioxane solution in which was dissolved 0.95 g of t-butyl α-{3(S)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-2-oxo-6(R)-phenylperhydroazepin-1-yl}acetate (Isomer A-2) [prepared as described in Example 1(l)] were allowed to stand for 16 hours; at the end of this time, the solvent was distilled off, and the syrupy residue was mixed with a small amount of ethyl acetate and diisopropyl ether and then filtered, to give 0.80 g of the title compound as a crystalline powder, melting at 200°-202° C.

Provenance & Evidence