HCID 20067388, compound → HCID 14097968, compound

HRID 569761Notes

Reaction equation

HRID 569761 reaction equation
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][NH:4][C:3]1=[S:8].C(O)(=O)C.C(O)(=O)C.[OH:17][C:18]1[C:19]([CH2:28]O)=[CH:20][C:21]2[O:26][CH2:25][CH2:24][CH2:23][C:22]=2[CH:27]=1>>[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][N:4]=[C:3]1[S:8][CH2:28][C:19]1[C:18]([OH:17])=[CH:27][C:22]2[CH2:23][CH2:24][CH2:25][O:26][C:21]=2[CH:20]=1

Participants

3

Reactant 2

HCID 20067388HCID 20067388, compoundHCID 86742067HCID 86742067, compound

Product 1

HCID 14097968HCID 14097968, compoundYield 29.2%

Procedure

In a manner analogous to Example 1, 1,5-dimethylimidazole-2-thione (0.80 g, 6.25 mmal) was treated with 6-hydroxy-7-hydroxymethyl-1,2,3,4-tetrahydrobenzopyran diacetate (1.70 g, 6.25 mmal) to afford 7-(((1,5-dimethyl-1H-imidazole-2-yl)thio)methyl)-6-hydroxy-1,2,3,4-tetrahydrobenzopyran (480 mg, 26%) mp 139°-140° C.

Sources & evidence

ORD record
ord-22f7560b7ad54ef394d6c28f286c48e8
Source dataset
uspto-grants-1988_03
Patent number
US04734421

Reaction notes

Loading…