反应详情

A mixture of 6-(4-aminophenyl)-3(2H)-pyridazinone (3.7 g) and 2,5-dimethoxytetrahydrofuran (2.6 g) in glacial acetic acid (37 ml) is heated under reflux for four hours. The reaction mixture is cooled, filtered and the solid is washed with ethanol, and finally crystallized from methanol to give 1.2 g of the product, 4,5-dihydro-6-[4-(1H)-pyrrol-1-yl)phenyl]-3(2H)-pyridazinone, mp 222°-223° C.

1. temperatureis heated
2. temperatureunder reflux for four hours
3. temperatureThe reaction mixture is cooled
4. filtrationfiltered
5. washthe solid is washed with ethanol
6. customfinally crystallized from methanol