Imidazole → HCID 20146342, compound

Participants

Reaction Steps

Potassium-t-butoxide (0.56 g, 0.5 mmol) is added to a solution of imidazole (0.34 g, 0.5 mmol) in dry DMF (10 ml) under N2. The resulting mixture is stirred until homogeneous and then five minutes longer. A solution of 4,5-dihydro-6-(2-chloroethoxyphenyl)-3(2H)-pyridazinone (1.27 g, 0.5 mmol) in dry DMF (20 ml) is added in one portion and the resultant mixture is heated and stirred at 60° for 12 hours. The DMF is then distilled off and the residue taken up in chloroform. The chloroform solution is extracted with 5% aqueous HCl. The aqueous extract is made basic with 10% aqueous sodium carbonate and extracted several times with methylene chloride. The methylene chloride is evaporated, leaving behind 0.45 g of the product 4,5-dihydro-6-[4-(2-(1H-imidazol-1-yl)ethoxyphenyl]-3(2H)-pyridazinone as an amorphous solid.

Provenance & Evidence