Sodium Hydroxide → N-[4-(1,4,5,6-Tetrahydro-6-oxo-3-pyridazinyl)phenyl]thiourea

HRID 569776Notes

Reaction equation

HRID 569776 reaction equation
[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[S:25])[NH:16]C(=O)C3C=CC=CC=3)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[OH-].[Na+]>C(O)C.O>[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:15]([NH2:16])=[S:25])=[CH:12][CH:13]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 13887378HCID 13887378, compound

Product 1

HCID 13274759N-[4-(1,4,5,6-Tetrahydro-6-oxo-3-pyridazinyl)phenyl]thioureaYield 81.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a suspension of 0.7 g of N-[[[4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)phenyl]amino]thioxomethyl]benzamide in 7 ml of ethanol is added 1.6 ml of 10% ethanolic sodium hydroxide followed by heating for two hours. The reaction mixture is cooled, diluted with water, and filtered to give 0.4 g of the product, N-[4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)phenyl]thiourea mp 234°-235° C.

Workup

  1. temperatureby heating for two hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-7eba5b8f72464605a8e609a0f4fcdc6b
Source dataset
uspto-grants-1988_03
Patent number
US04734415

Reaction notes

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