Potassium Carbonate → HCID 13887377, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.57 g of 4,5-dihydro-6-[4-(isothiocyano)phenyl]-3(2H)-pyridazinone, 0.51 g of 2-bromoethylamine hydrobromide and 0.34 g of anhydrous K2CO3 in 12 ml of DMF is heated at 80° C. for four hours. The reaction mixture is cooled, filtered, and the filtrate is concentrated under reduced pressure. The residue is treated with water, neutralized, and filtered to give 0.5 g of 6-[4-[(4,5-dihydro-2-thiazolyl)amino]phenyl]-4,5-dihydro-3(2H)-pyridazinone, mp 217°-218° C.

Provenance & Evidence