Dimethylamine → 5-[4-(Dimethylamino)benzoyl]-4-methyl-1,3-thiazol-2(3H)-one

Participants

Reaction Conditions

Reaction Steps

Dimethylamine (100 ml, 40% solution) was added to a solution of 5-(4-fluorobenzoyl)-4-methyl-2(3H)-thiazolone (4.7 g) in ethanol (200 ml). The mixture was stirred in a sealed stainless steel vessel at 120° C. for 16 hours. After cooling to ambient temperature the solvent and excess dimethylamino was evaporated. The residue was recrystallized twice from ethanol to give the title compound, mp. 224°-226° C.

Provenance & Evidence