HCID 4321391, compound → 1-[2-Acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester

HRID 569876Notes

Reaction equation

HRID 569876 reaction equation
[C:1]([S:4][CH2:5][CH:6]([CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)=[O:15])[C:7]([OH:9])=O)(=[O:3])[CH3:2].[C:26]([NH:29][CH:30]([C:36]([OH:38])=[O:37])[CH2:31]SC(=O)C)(=O)[CH3:27]>>[C:6]([O:38][C:36](=[O:37])[C@@H:30]1[CH2:31][CH2:27][CH2:26][N:29]1[C:7](=[O:9])[CH:6]([CH2:5][S:4][C:1](=[O:3])[CH3:2])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)=[O:15])([CH3:10])([CH3:7])[CH3:5]

Participants

3

Reactant 2

HCID 4321391HCID 4321391, compoundHCID 12774426HCID 12774426, compound

Product 1

HCID 228053291-[2-Acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester

Procedure

By substituting 2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoic acid for the N,S-diacetyl-D,L-cysteine in the procedure of Example 53, N-[2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester is obtained.

Sources & evidence

ORD record
ord-2569540ed5a542eea454cbdb59dfe91a
Source dataset
uspto-grants-1988_03
Patent number
US04734420

Reaction notes

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