反应详情

2.1 g. of the product from Example 81 is dissolved in a mixture of water (40 ml.) and concentrated ammonia (40 ml.). After one hour the reaction mixture is concentrated to 1/3 volume, and applied to a column of Dowex 50 resin in the hydrogen cycle. The product is eluted with water. The aqueous is extracted with ethyl acetate and then concentrated to dryness to yield 1.4 g. of the named product Rf : 0.50 (silica gel-Chloroform:methanol:acetic acid:water).

1. concentrationAfter one hour the reaction mixture is concentrated to 1/3 volume
2. washThe product is eluted with water
3. extractionThe aqueous is extracted with ethyl acetate
4. concentrationconcentrated to dryness
5. customto yield 1.4 g