HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → HCID 57144783, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-methyl-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-4-one | HCID 20146596 | — |
| Catalyst | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57144783 | HCID 57144783 | — |
Reaction Steps
A mixture of 7 grams of 5,6,7,8-tetrahydro-1-methyl4(1H)-cycloheptapyrazolone, 2.3 grams of sodium hydride (97%), 12 ml of ethyl formate, 2 drops of ethanol and 100 ml of tetrahydrofuran was heated at reflux for 3 hours. The mixture was then cooled and partitioned between water and ether. The aqueous layer was washed once with ether and acidified to a pH of 5 with 1 N hydrochloric acid. The white precipitate which formed was separated by filtration and dried to give 5,6,7,8-tetrahydro-5-hydroxymethylene-1-methyl-4(1H)-cycloheptapyrazolone as a cream colored powder melting at about 133°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04734430 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-8bb048309e6e435f9e9ef975be0f0aac |
| Source note | uspto-grants-1988_03 |