Glycine → HCID 10176752, compound

HRID 569935Notes

Reaction equation

HRID 569935 reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[C:6](Cl)(=[O:15])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[OH-].[Na+]>O.CCOCC>[C:6]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[O:15])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

6

Reactant 3

HCID 750GlycineHCID 14798Sodium HydroxideHCID 69819Nonanoyl chloride

Product 1

HCID 10176752HCID 10176752, compoundYield 79.5%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

Glycine (20 mmol) was reacted with nonanoyl chloride (22 ml) in the presence of NaOH (40 mmol) in a mixture of water and ether as described in Example 1 Part A. The crude crystalline product (4.25 g) was recrystallized from ethyl acetate (40-50 ml) to give the title compound (3.42 g, 79.5%), m.p. 106°-109° C.

Workup

  1. customThe crude crystalline product (4.25 g) was recrystallized from ethyl acetate (40-50 ml)

Sources & evidence

ORD record
ord-53df7cdd58d64abcbaffbf5a5604cb7b
Source dataset
uspto-grants-1988_03
Patent number
US04734424

Reaction notes

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