Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(4-Hydroxyphenyl)propionic acid → 2-[3-(4-Hydroxyphenyl)propionylamino]acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(4-Hydroxyphenyl)propionic acid | HCID 10394 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-[3-(4-Hydroxyphenyl)propionylamino]acetic acid ethyl ester | HCID 10264158 | — |
반응 단계
3-(4-Hydroxyphenyl)propionic acid (2.49 g, 15 mmol) was reacted with glycine ethyl ester hydrochloride in the presence of CDI and Et3N as described in Example 56 Part A. After removal of the solvent the residue was dissolved in CHCl3 and washed with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution. After drying (MgSO4) and removal of the solvent in vacuo crude title ester remained (2.44 g) as a viscous oil. NMR indicated this contained a major impurity but it was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04734424 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-2f610ca1fde24011bcaed02150a9b629 |
| 출처 메모 | uspto-grants-1988_03 |