Glycine → Phenylpropionylglycine

Participants

Reaction Steps

Glycine (1.5 g, 20 mmol) and hydrocinnamoyl chloride (3.37 g, 22 mmol) were reacted in the presence of NaOH (40 mmol) in a mixture of water and ether using the method described in Example 5 Part A. The crude product was extracted into chloroform, dried (MgSO4) and freed of solvent in vacuo leaving a near white solid (3.53 g, 85%) This was recrystallized from EtOAc (13 ml) to give title compound (2.66 g, 64%) m.p. 112-114° C.

Provenance & Evidence