HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → US10183932, Example 62
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-({2-[4-(5-chloro-2-cyanophenyl)-5-isopropoxy-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate | HCID 117622846 | — |
| Product | US10183932, Example 62 | HCID 117622998 | — |
Reaction Steps
31 mg (0.06 mmol) of tert-butyl 4-({2-[4-(5-chloro-2-cyanophenyl)-2-oxo-5-(propan-2-yloxy)pyridin-1(2H)-yl]propanoyl}amino)benzoate (racemate) (Example 24.11) were hydrolysed with TFA according to General Method 2. Yield: 5 mg (18% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-d6a4e41acbc44a3691047555807b6c5a |
| Source note | uspto-grants-2016_09 |