Aluminum(III) Chloride → HCID 12899140, compound

HRID 569951Notes

Reaction equation

HRID 569951 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 12899436HCID 12899436, compound

Product 1

HCID 12899140HCID 12899140, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The thus-obtained 13 g of 8-chloro-5-methoxy-3,4-dihydrocarbostyril and 35 g of aluminum chloride are dispersed in 30 ml of benzene and heated for 2 hours under refluxing conditions. The reaction mixture is poured into ice-water and the precipitate thus formed is separated by filtration, washed with water and dried. Recrystallization from isopropanol obtains 8 g of 8-chloro-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 206°-207° C.

Workup

  1. temperatureheated for 2 hours under refluxing conditions
  2. customthe precipitate thus formed
  3. customis separated by filtration
  4. washwashed with water
  5. customdried
  6. customRecrystallization from isopropanol

Sources & evidence

ORD record
ord-0f66c0a5f3f443c6b43d8a74d0d45d70
Source dataset
uspto-grants-1988_03
Patent number
US04734416

Reaction notes

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