Water → HCID 13784093, compound

Participants

Reaction Conditions

Reaction Steps

Added to a 1 l flask were 40 g (0.128 mol) of the ethyl 2-(4-benzylpiperazino)-4-methylpyrimidine-5-carboxylate, 11 g of KOH, 200 ml of H2O and 500 ml of EtOH. The contents were stirred at 100° C. for 0.5 hr. Thereafter, the solvent was distilled off under reduced pressure. One liter of H2O was then added to the residue and the resulting mixture was adjusted to pH 4 with conc. hydrochloric acid. The precipitated crystals were filtered off and the filtrate was dried under reduced pressure, thereby obtaining 36 g of the intended compound as a white solid substance (yield: 98%).

Provenance & Evidence