HCID 13670002, compound → HCID 13670004, compound

HRID 569986Notes

Reaction equation

HRID 569986 reaction equation
[CH2:1]([N:3]1[CH:25]=[CH:24][C:6]2[NH:7][C:8]([N:11]3[CH2:16][CH2:15][N:14](CC4C=CC=CC=4)[CH2:13][CH2:12]3)=[N:9][CH2:10][C:5]=2[C:4]1=[O:26])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([N:3]1[CH:25]=[CH:24][C:6]2[NH:7][C:8]([N:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)=[N:9][CH2:10][C:5]=2[C:4]1=[O:26])[CH3:2]

Participants

5

Reactant 2

HCID 13670002HCID 13670002, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13670004HCID 13670004, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Dissolved in 20 ml of ethanol was 1.0 g of the 1,4,5,6-tetrahydro-6-ethyl-5-oxo-2-(4-benzylpiperazino)pyrido[4,3-d]pyrimidine obtained in Referential Example 31, followed by an addition of 10% Pd-C. The resultant mixture was stirred at 70° C. for 2.5 hours in a hydrogen atmosphere. After removal of the catalyst by filtration, the filtrate was concentrated to obtain 0.7 g of 1,4,5,6-Tetrahydro-6-ethyl-5-oxo-2-piperazinopyrido[4,3-d]pyrimidine as crystals (yield: 95%).

Workup

  1. customobtained in Referential Example 31
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f4707bb5a7cd4d68aef7753c82b281be
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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