反应详情

To a suspension which had been obtained by adding 1.56 g of 1-amidino-4-benzylpiperazine sulfate to an ethanol solution of 0.23 g of sodium hydroxide, 1.07 g of 1-ethyl-3-methoxymethylenepiperidine-2,4-dione (Referential Example 37) was added. The resultant mixture was refluxed for 2 hours. After distilling off ethanol, water was added to the residue, followed by extraction with chloroform. After drying the chloroform layer, it was concentrated to obtain 1.4 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (yield: 69%).

1. customTo a suspension which had been obtained
2. additionwas added
3. distillationAfter distilling off ethanol, water
4. additionwas added to the residue
5. extractionfollowed by extraction with chloroform
6. dry with materialAfter drying the chloroform layer, it
7. concentrationwas concentrated