反应详情

Dissolved in 20 ml of ethanol was 0.70 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (Referential Example 38), followed by an addition of 10% Pd-C. The resultant mixture was stirred at 60° C. for 4 hours in a hydrogen atmosphere. After allowing the reaction mixture to cool down, the catalyst was filtered off and the filtrate was concentrated to obtained 0.50 g of 6-ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as crystals (yield: 96%). The crystals were purified by their immersion in ethyl acetate.

1. temperatureto cool down
2. filtrationthe catalyst was filtered off
3. concentrationthe filtrate was concentrated