Ethyl Bromide → HCID 13784146, compound

Participants

Reaction Conditions

Reaction Steps

Added to 30 ml of THF were 0.65 g (1.84 mmol, Referential Example 51) of 2-(4-benzylpiperazino)-6-oxo-6,7,8,9-tetrahydro(5H)pyrimido[5,4-b]azepine and 0.15 g (3.75 mmol) of 60% NaH. The resultant mixture was stirred at 20° C. for 30 minutes. Thereafter, 3 g (27.8 mmol) of ethyl bromide was added and the reaction mixture was heated to 60° C. at which the reaction was conducted for 5 hours. After completion of the reaction, the solvent was distilled off and the residue was purified by silica gel column chromatography to obtain 0.65 g of a colorless oil (yield: 92%).

Provenance & Evidence