Isopropanol → HCID 13784149, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.41 g (3.76 mmol, Referential Example 71) of ethyl 2-(4-benzylpiperazino)-4-chloropyrimidine-5-acetate, 5 ml of ethylamine and 20 ml of isopropanol was placed in a pressure vessel, in which they were heated at 120° C. for 2 hours. The solvent was then driven off under reduced pressure. The residue was added with water, followed by extraction with chloroform. After drying the organic layer with MgSO4, it was concentrated. The residue was purified by silica gel column chromatography to obtain 0.58 of the above-identified compound (yield: 46%).

Provenance & Evidence