Ethanol → HCID 13923938, compound

Participants

Reaction Steps

Refluxed for 5 hours in isoamyl alcohol (30 ml) were 1.74 g (7.3 mmol) of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 1.60 g (7.3 mmol) of the 6-piperazino-2-methyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidine synthesized in Referential Example 82. After allowing the reaction mixture to cool down, the resultant crystals were collected by filtration and then washed with ethanol. The thus-obtained crude crystals were added with ethanol and refluxed for 2 hours. After allowing the mixture to cool down, crystals were collected by filtration and then dried to obtain 2.90 g of the above-identified compound (yield: 84%).

Provenance & Evidence