Hydrochloric Acid → HCID 10088282, compound

Participants

Reaction Steps

In this Example, 150 mg (0.45 m mole) of the trifluoroacetate of (±)-cis-7-amino-3-chloro-1-azabicyclo-[4,2,0]oct-2-en-8-on-2-carboxylic acid prepared as in the method described in JPUPA No. 87791/80 is dissolved in a mixture of 2 ml of water and 2 ml of acetone and 134 mg (1.5 m mole) of sodium bicarbonate is added to the solution to make the solution homogeneous. To the mixture is added 84.2 mg (0.54 mole) of phenylacetylchloride dissolved in 0.5 ml of acetone under cooling in one hour and the mixture is stirred for 3 hours. The reaction mixture is added to a pH of 2 with 1N hydrochloric acid and extracted 5 times with 2 ml of ethyl acetate. The extract is concentrated under reduced pressure and dried to obtain 80 mg (55.0%) of the desired compound.

Provenance & Evidence