Sodium Carbonate → 4-[7-Chloro-4-cinnolinylamino]-N-(2-diethylaminoethyl)benzenesulphonamide

Participants

Reaction Conditions

Reaction Steps

A mixture of anhydrous sodium carbonate (3.08 g) and N,N-diethylethylenediamine (0.43 ml) in chloroform (30 ml) was vigorously stirred at 5° C. and treated with 4-(7-Chloro-4-cinnolinylamino)benzenesulphonyl chloride hydrochloride (1.0 g). The mixture was stirred at room temperature for 11/2 hours and then filtered. The filtrate was evaporated to give a residue that crystallised from ethanol to give the title compound (0.456 g), m.p. 175°-76° C.

Provenance & Evidence