Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trityl chloride → Ethyl 1-tritylpyrazole-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trityl chloride | HCID 6456 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | ethyl 1H-pyrazole-4-carboxylate | HCID 142179 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl 1-tritylpyrazole-4-carboxylate | HCID 10523968 | 82% |
반응 단계
Ethyl pyrazole-4-carboxylate (W. Holtzer, G. Seiringer, J. Heterocyclic Chem., 1993, 30, 865) (1.7 g, 12.1 mmol) and NaH (680 mg, 60% in mineral oil, 16.94 mmol) reacted in dry DMF for 1 h. Then, trityl chloride (3.373 g, 12.1 mmol) was added, and the reaction mixture stirred for 3 days at room temperature. The title compound was recovered as described in example 2a for 3,5-dimethyl-4-ethylacetate-1-tritylpyrazole. Yield: 82% (3.79 g, 4 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09023315B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-0c3890d302e840109a782cf21e76e7b1 |
| 출처 메모 | uspto-grants-2015_05 |