HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-Trityl-4-methoxymethylpyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (1-Trityl-1H-pyrazol-4-yl)methanol | HCID 10688521 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Trityl-4-methoxymethylpyrazole | HCID 68530902 | 93% |
Reaction Steps
This compound is obtained by reacting 1-trityl-4-hydroxymethylpyrazole (555 mg; 1.63 mmol) in dry tetrahydrofuran with sodium hydride (98 mg; 2.44 mmol) and iodomethane (0.5 mL; 8.15 mmol). Yield: 93% (536 mg, 1.51 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023315B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-43ed1bcb2315415481cb713c6d8ab10b |
| Source note | uspto-grants-2015_05 |