6-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one → (2-Amino-5-methoxyphenyl)(4-chlorophenyl)methanone

To a solution of 2-methyl-6-(methyloxy)-4H-3,1-benzoxazin-4-one (for a preparation see Reference compound A) (40.0 g, 0.21 mol) in a toluene/ether (2/1) mixture (760 mL) at 0° C. was added dropwise a solution of 4-chlorophenylmagnesium bromide (170 mL, 1M in Et2O, 0.17 mol). The reaction mixture was allowed to warm to room temperature and stirred for 1 h before being quenched with 1N HCl (200 mL). The aqueous layer was extracted with EtOAc (3×150 mL) and the combined organics were washed with brine (100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The crude compound was then dissolved in EtOH (400 mL) and 6N HCl (160 mL) was added. The reaction mixture was refluxed for 2 h before being concentrated to one-third in volume. The resulting solid was filtered and washed twice with ether before being suspended in EtOAc and neutralised with 1N NaOH. The aqueous layer was extracted with EtOAc (3×150 mL) and the combined organics were washed with brine (150 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The title compound was obtained as a yellow solid (39 g, 88% yield); LC/MS (Method A): m/z 262 [M+H]+, Rt 2.57 min.

1. customat 0° C.
2. custombefore being quenched with 1N HCl (200 mL)
3. extractionThe aqueous layer was extracted with EtOAc (3×150 mL)
4. washthe combined organics were washed with brine (100 mL)
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. dissolutionThe crude compound was then dissolved in EtOH (400 mL)
9. addition6N HCl (160 mL) was added
10. temperatureThe reaction mixture was refluxed for 2 h
11. concentrationbefore being concentrated to one-third in volume
12. filtrationThe resulting solid was filtered
13. washwashed twice with ether
14. extractionThe aqueous layer was extracted with EtOAc (3×150 mL)
15. washthe combined organics were washed with brine (150 mL)
16. dry with materialdried over Na2SO4
17. filtrationfiltered
18. concentrationconcentrated under reduced pressure

ORD record

ord-d4dd1c708c654843aab86fe7332efcee

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09023842B2