2-Pyridinemethanamine → 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (pyridin-2-ylmethyl)-amide

関与物質

反応手順

This compound was prepared in an analogous manner as 3-{[3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester using 2-(aminomethyl)pyridine instead of 1-BOC-3-aminopyrrolidine. LCMS (ESI) 350 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 11.55 (1H, br. s.) 10.25 (1H, s) 8.75 (1H, t, J=5.95 Hz) 8.43-8.49 (1H, m) 8.02 (1H, d, J=5.47 Hz) 7.83 (1H, d, J=5.27 Hz) 7.69-7.77 (1H, m) 7.49 (1H, d, J=5.47 Hz) 7.28-7.34 (2H, m) 7.21-7.27 (1H, m) 6.82 (1H, d, J=5.47 Hz) 6.41 (1H, dd, J=3.51, 1.76 Hz) 4.55 (2H, d, J=6.05 Hz)

情報源と証拠