Tert-butyl 1-aminopiperidine-4-carboxylate → (4-Amino-piperidin-1-yl)-[3-(1H-pyrrolo[2,3-b]pyridin-4-ylamino)-thiophen-2-yl]-methanone

Participants

Reaction Steps

This compound was prepared in an analogous manner as 3-{[3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester using 4-Boc-aminopiperidine instead of 1-BOC-3-aminopyrrolidine. LCMS (ESI) 342 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 12.52 (1H, s) 10.36 (1H, s) 8.18 (1H, d, J=4.10 Hz) 8.04 (1H, d, J=7.03 Hz) 7.87 (1H, d, J=5.08 Hz) 7.33-7.37 (1H, m) 7.15 (1H, d, J=5.27 Hz) 6.53 (1H, d, J=7.03 Hz) 3.54 (4H, s) 2.81-2.94 (1H, m) 1.82 (2H, d, J=9.96 Hz) 1.70-1.76 (1H, m) 1.25-1.39 (2H, m)

Provenance & Evidence