3-Chloro-4-(trifluoromethyl)benzylamine → 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid 4-chloro-3-trifluoromethyl-benzylamide

Participants

Reaction Steps

This compound was prepared in an analogous manner as 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (2-amino-ethyl)-amide using 3-chloro-4-(trifluoromethyl)benzylamine instead of tert-butyl-2-amino ethyl carbamate. LCMS (ESI) 451 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 11.54 (1H, br. s.) 10.24 (1H, s) 8.76 (1H, t, J=5.98 Hz) 8.02 (1H, d, J=5.47 Hz) 7.82 (2H, d, J=4.05 Hz) 7.65-7.71 (1H, m) 7.58-7.64 (1H, m) 7.50 (1H, d, J=5.42 Hz) 7.30 (1H, dd, J=3.29, 2.56 Hz) 6.84 (1H, d, J=5.42 Hz) 6.40 (1H, dd, J=3.49, 1.93 Hz) 4.52 (2H, d, J=5.91 Hz)

Provenance & Evidence