HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Aminophenyl)-1,3-oxazol-2(3H)-one → HCID 117622778, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Aminophenyl)-1,3-oxazol-2(3H)-one | HCID 117622793 | — |
| Reactant | 2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-cyclobutylpropanoic acid | HCID 117622853 | — |
| Product | HCID 117622778 | HCID 117622778 | — |
Reaction Steps
103 mg (purity 94%, 0.25 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-cyclobutylpropanoic acid (racemate) and 55 mg (0.28 mmol, 1.1 eq.) of 5-(4-aminophenyl)-1,3-oxazol-2(3H)-one were reacted according to General Method 1. The crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 36 mg (27% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-9729ecca1af54e5591291a160be1833f |
| Source note | uspto-grants-2016_09 |