tert-Butyl {2-amino-2-[4-(trifluoromethyl)phenyl]ethyl}carbamate → HCID 50923290, compound

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Reaction Steps

This compound was prepared in an analogous manner as 3-{[3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester using tert-butyl [2-amino-2-(4-trifluoromethylphenyl)ethyl]carbamate instead of 1-BOC-3-aminopyrrolidine. LCMS (ESI) 446 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 12.48 (1H, br. s.) 10.92 (1H, s) 9.40 (1H, d, J=8.00 Hz) 8.28 (3H, br. s.) 8.01 (1H, d, J=6.83 Hz) 7.95 (1H, d, J=5.27 Hz) 7.53-7.58 (2H, m) 7.47-7.52 (2H, m) 7.43 (1H, d, J=2.54 Hz) 7.31 (1H, d, J=5.27 Hz) 7.00 (1H, br. s.) 6.55 (1H, d, J=7.03 Hz) 5.39 (1H, td, J=8.79, 4.30 Hz) 3.19 (1H, t, J=10.93 Hz)

Provenance & Evidence