反应详情

Under an argon atmosphere, 685 mg (purity 84%, approx. 2.273 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile were dissolved in 8 ml of absolute methanol. 127 mg (2.273 mmol) of sodium methoxide were added and the mixture was stirred at RT for 1 h. 532 mg (8.864 mmol) of acetic acid and 299 mg (2.273 mmol) of ammonium chloride were added and the mixture was boiled under reflux for 45 min. The reaction mixture was concentrated, the residue was stirred with 20 ml of 1N sodium hydroxide solution, and the precipitate was filtered off with suction and dried under high vacuum. 610 mg (purity 86%, 86% of theory) of the target compound were obtained.

1. temperatureunder reflux for 45 min
2. concentrationThe reaction mixture was concentrated
3. stirringthe residue was stirred with 20 ml of 1N sodium hydroxide solution
4. filtrationthe precipitate was filtered off with suction
5. customdried under high vacuum
6. custom610 mg (purity 86%, 86% of theory) of the target compound were obtained