HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Chloromethyl)-3-fluoropyridine → 6-Chloro-1-[(3-fluoropyridin-2-yl)methyl]-1H-indazole-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Chloromethyl)-3-fluoropyridine | HCID 15133602 | — |
| Reactant | 6-Chloro-1H-indazole-3-carbonitrile | HCID 53408402 | — |
| Product | 6-Chloro-1-[(3-fluoropyridin-2-yl)methyl]-1H-indazole-3-carbonitrile | HCID 86692112 | 92.7% |
Reaction Steps
2.3 g (12.95 mmol) of 6-chloro-1H-indazole-3-carbonitrile (WO 2011/149921, Expl. 58C) were reacted in analogy to Example 53A with 2.07 g (14.25 mmol) of 2-(chloromethyl)-3-fluoropyridine. 3.44 g of the title compound were obtained (93% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023849B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-47da1088287f49998a06905243c81747 |
| Source note | uspto-grants-2015_05 |