HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2,6-dichloro-9-cyclohexyl-9H-purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Iodocyclohexane | HCID 12289 | — |
| Reactant | 2,6-Dichloropurine | HCID 5324412 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2,6-dichloro-9-cyclohexyl-9H-purine | HCID 20341610 | 41% |
Reaction Steps
2,6-Dichloropurine (1 mmol), powdered potassium carbonate (4 mmol) and cyclohexyliodide were vigorously stirred in 5 mL DMSO overnight. After evaporation of the solvent the product was extracted (water/diethylether) and purified by column chromatography (silicagel/1% MeOH in CHCl3). Crystallization from diethylether gave product in 41% yield, mp 116-121° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023857B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-75f174a3bf01459fb4db87c03d30f52f |
| Source note | uspto-grants-2015_05 |