反应详情

温度

165 °C

A mixture of 5-(piperazin-1-yl)-3-p-tolyl-1,2,4-thiadiazole (17.3 mg, 66.4 μmol), 1-(chloromethyl)-2-methylbenzene (14.0 mg, 99.7 μmol) and DIPEA (42.9 mg, 58.0 μl) in 0.8 mL N-Methyl-2-pyrrolidinone was heated in the microwave oven 165° C. for 12.5 min. The resulting reaction mixture solution was purified by preparative HPLC on reversed phase eluting with a gradient formed from MeCN, water and NEt3 to yield after evaporation of the product containing fractions 17.5 mg (72%) of the title compound as yellow viscous oil. MS (m/e): 365.3 (MH+).

1. customThe resulting reaction mixture solution
2. customwas purified by preparative HPLC on reversed phase
3. washeluting with a gradient
4. customformed from MeCN, water and NEt3
5. customto yield
6. customafter evaporation of the product
7. additioncontaining fractions 17.5 mg (72%) of the title compound as yellow viscous oil