1-(2-Bromoethyl)-4-chlorobenzene → HCID 71503358, compound

HRID 570577Notes

Reaction equation

HRID 570577 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25]N=[C:23](OC)[CH:22]=4)[CH2:15][CH2:14]3)[S:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.[Cl:29][C:30]1SN=C(C2C=CN=C(Cl)C=2)N=1.BrCCC1C=CC(Cl)=CC=1>>[Cl:29][C:30]1[CH:25]=[CH:26][C:21]([CH2:20][CH2:19][N:16]2[CH2:17][CH2:18][N:13]([C:11]3[S:10][N:9]=[C:8]([C:6]4[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=4)[N:12]=3)[CH2:14][CH2:15]2)=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 230291-(2-Bromoethyl)-4-chlorobenzeneHCID 71503051HCID 71503051, compoundHCID 86718160HCID 86718160, compound

Product 1

HCID 71503358HCID 71503358, compound

Procedure

In analogy to the procedure described for the synthesis of 3-(2-chloropyridin-4-yl)-5-(4-(2-(2-methoxypyridin-4-yl)ethyl)piperazin-1-yl)-1,2,4-thiadiazole (Example 168), the tile compound was prepared from 5-chloro-3-(2-chloropyridin-4-yl)-1,2,4-thiadiazole and 1-(2-bromoethyl)-4-chlorobenzene.

Sources & evidence

ORD record
ord-35e654f2973b41389a868a2ce2e672a8
Source dataset
uspto-grants-2015_05
Patent number
US09023852B2

Reaction notes

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